Inositol phosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Inositol phosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEF2C, ARHGEF6, and RAC3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inositol phosphate metabolic process activity versus MEF2C in UCEC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEF2C →	+0.516	+0.731	.002	.005	3	7
LSCC	ARHGEF6 →	+0.517	+0.728	<.001	<.001	3	6
BRCA	RAC3 →	-0.636	-0.690	.009	<.001	3	6
LUAD	CD302 →	+0.388	+0.516	<.001	.001	3	6
LSCC	FLI1 →	+0.572	+0.770	<.001	<.001	3	6
LSCC	JAM2 →	+0.410	+0.791	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043647 vs MEF2C — UCEC

Explore this scatter interactively →