Inositol phosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Inositol phosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GJA1, UQCRB, and CD83, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GJA1 grouped by Inositol phosphate metabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GJA1 →	+2.889	+1.609	.001	<.001	3	4
BLOOD_Lymphoma	UQCRB →	+0.809	+1.570	<.001	.009	3	4
STOMACH	CD83 →	+1.666	+1.212	.006	.003	3	4
STOMACH	HSD11B2 →	-1.604	-0.990	.006	.002	3	4
LUNG_NSCLC_LUSC	NCOR2 →	+0.981	+1.471	<.001	<.001	3	4
KIDNEY	CHDH →	-0.808	-1.431	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GJA1 by Inositol phosphate metabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →