Inositol phosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Inositol phosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMM44, WRAP53, and WDR54, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inositol phosphate metabolic process activity versus TIMM44 in BONE (Pearson r = -0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TIMM44 →	-1.839	-1.456	.001	<.001	3	5
URINARY_TRACT	WRAP53 →	-0.985	-1.384	.005	.007	3	4
BLOOD_Leukemia	WDR54 →	-1.426	-0.386	<.001	<.001	3	4
BLOOD_Leukemia	PAFAH1B1 →	-0.576	-0.305	.001	.003	3	4
BONE	SNRPD2 →	-0.444	-0.886	.002	.006	3	4
LIVER	PRPSAP2 →	-1.331	-0.290	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043647 vs TIMM44 — BONE

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