Response to estrogen

Across TCGA patient cohorts, RNA activity of the Response to estrogen pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL8A1, KIF26B, and COL5A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to estrogen activity versus COL8A1 in OV (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COL8A1 →	+1.732	+0.112	<.001	.006	3	7
OV	KIF26B →	+1.264	+0.134	<.001	.004	3	6
BRCA	COL5A1 →	+0.903	+0.152	.009	.002	3	6
BRCA	ANTXR1 →	+0.692	+0.110	.002	.001	3	6
OV	INHBA →	+1.597	+0.129	.002	.004	2	6
OV	CDH11 →	+1.223	+0.125	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043627 vs COL8A1 — OV

Explore this scatter interactively →