Response to estrogen

Across TCGA cell cohorts, RNA activity of the Response to estrogen pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM135, TUBA4A, and RPS6KA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM135 grouped by Response to estrogen-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TMEM135 →	+1.385	+0.338	<.001	.003	3	4
SOFT_TISSUE	TUBA4A →	-4.828	-0.290	<.001	<.001	3	4
SOFT_TISSUE	RPS6KA2 →	-2.029	-0.235	.003	.004	3	4
BREAST	EPN3 →	+2.979	+0.495	<.001	.001	3	4
STOMACH	PODXL →	-2.929	-1.048	<.001	.002	3	4
STOMACH	TAGLN2 →	-1.523	-1.473	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM135 by Response to estrogen activity — SOFT_TISSUE

Explore this box plot interactively →