Response to estrogen

Across TCGA cell cohorts, RNA activity of the Response to estrogen pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPL, TINAGL1, and SLC25A6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to estrogen activity versus PPL in OVARY (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PPL →	+2.397	+0.213	<.001	.003	3	8
LUNG_NSCLC_LUAD	TINAGL1 →	+2.623	+0.287	.001	<.001	3	7
OVARY	SLC25A6 →	-1.190	-0.241	.001	.001	3	6
LUNG_NSCLC_LUAD	P2RY2 →	+1.992	+0.299	<.001	<.001	3	6
KIDNEY	AK6 →	-1.107	-0.435	<.001	.001	3	6
OVARY	PITPNM3 →	+1.097	+0.298	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043627 vs PPL — OVARY

Explore this scatter interactively →