Astrocyte cell migration

Across TCGA cell cohorts, RNA activity of the Astrocyte cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCL2, GPR183, and DYNC2H1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCL2 grouped by Astrocyte cell migration-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CCL2 →	-0.362	-1.982	<.001	<.001	3	9
OVARY	GPR183 →	-0.377	-1.452	<.001	<.001	3	8
LUNG_NSCLC_LUSC	DYNC2H1 →	-0.487	-1.331	.004	<.001	3	6
LUNG_NSCLC_LUAD	SLC39A13 →	-0.210	-0.746	.001	.002	3	6
BLOOD_Myeloma	MLC1 →	-0.713	-1.863	.006	<.001	2	6
OVARY	NINJ1 →	-0.138	-1.085	.008	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCL2 by Astrocyte cell migration activity — BLOOD_Myeloma

Explore this box plot interactively →