Astrocyte cell migration

Across TCGA cell cohorts, RNA activity of the Astrocyte cell migration pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF2, ALG9, and ZSCAN9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLF2 grouped by Astrocyte cell migration-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KLF2 →	+2.485	+1.372	.005	.002	3	4
BONE	ALG9 →	-0.866	-1.299	<.001	.003	3	4
BLOOD_Leukemia	ZSCAN9 →	-1.503	-1.271	.003	.001	3	4
STOMACH	ITPA →	-0.607	-0.944	.006	.008	3	3
STOMACH	TRIM56 →	-1.520	-1.540	.003	<.001	3	3
STOMACH	SAMD9 →	-2.210	-1.010	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLF2 by Astrocyte cell migration activity — STOMACH

Explore this box plot interactively →