Skin morphogenesis

Across TCGA patient cohorts, RNA activity of the Skin morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN1, NID2, and RSU1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skin morphogenesis activity versus TLN1 in GBM (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TLN1 →	+0.367	+0.164	<.001	<.001	3	8
GBM	NID2 →	+0.468	+0.104	.001	.001	3	8
OV	RSU1 →	+0.396	+0.091	<.001	<.001	3	7
CCRCC	ACTN1 →	+0.552	+0.089	<.001	<.001	3	7
CCRCC	VCL →	+0.481	+0.075	<.001	<.001	3	7
OV	FN1 →	+0.771	+0.067	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043589 vs TLN1 — GBM

Explore this scatter interactively →