Skin morphogenesis

Across TCGA patient cohorts, RNA activity of the Skin morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL2, ATP2A3, and SARDH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skin morphogenesis activity versus IL2 in PDAC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	IL2 →	-0.249	-0.747	.001	<.001	3	5
LUAD	ATP2A3 →	-0.747	-0.897	<.001	<.001	3	5
BRCA	SARDH →	-0.549	-0.176	<.001	.001	3	4
BRCA	ADH6 →	+0.177	+0.274	.001	<.001	3	4
COAD	LINC01564 →	+0.554	+0.956	.001	<.001	3	4
HNSC	UCP2 →	-0.743	-0.857	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043589 vs IL2 — PDAC

Explore this scatter interactively →