Skin morphogenesis

Across TCGA cell cohorts, RNA activity of the Skin morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GABPB2, ATG4B, and PILRB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GABPB2 grouped by Skin morphogenesis-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GABPB2 →	+0.375	+0.483	.004	<.001	3	4
URINARY_TRACT	ATG4B →	+0.142	+0.620	.002	<.001	3	4
LUNG_NSCLC_LUAD	PILRB →	+0.121	+0.362	.001	.002	3	3
OESOPHAGUS	SLC5A4 →	-0.246	-0.378	<.001	.002	3	3
BLOOD_Leukemia	JMJD7 →	+0.193	+0.615	.004	.001	3	3
OESOPHAGUS	CRLF1 →	-0.138	-0.444	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GABPB2 by Skin morphogenesis activity — OESOPHAGUS

Explore this box plot interactively →