Nose development

Across TCGA cell cohorts, RNA activity of the Nose development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED3, PPIB, and ROBO3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMED3 grouped by Nose development-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TMED3 →	-0.612	-0.780	.004	.005	3	5
BREAST	PPIB →	-0.578	-0.623	.004	.005	2	5
LUNG_SCLC	ROBO3 →	-2.106	-1.247	.006	<.001	3	4
URINARY_TRACT	GRK6 →	-1.133	-1.800	.003	<.001	3	4
STOMACH	PIGT →	-1.059	-1.147	.002	.008	3	4
STOMACH	MIEF2 →	-1.503	-1.443	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMED3 by Nose development activity — SKIN

Explore this box plot interactively →