Nose development

Across TCGA cell cohorts, RNA activity of the Nose development pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTHFD1L, MDFIC, and TRIM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTHFD1L grouped by Nose development-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MTHFD1L →	+0.153	+1.538	.002	<.001	3	5
LUNG_NSCLC_LUAD	MDFIC →	-0.250	-1.381	.005	.004	3	5
PANCREAS	TRIM2 →	-0.141	-1.597	.006	<.001	3	4
PANCREAS	HRC →	+0.235	+1.014	.001	.004	3	4
URINARY_TRACT	FST →	-0.250	-1.737	.003	.001	3	3
URINARY_TRACT	ITGAL →	-0.176	-1.737	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTHFD1L by Nose development activity — LUNG_SCLC

Explore this box plot interactively →