Nose development

Across TCGA cell cohorts, RNA activity of the Nose development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH1A3, LTBP3, and ID4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nose development activity versus ALDH1A3 in LARGE_INTESTINE (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ALDH1A3 →	+4.611	+1.243	<.001	.003	3	8
OESOPHAGUS	LTBP3 →	+2.223	+1.441	<.001	<.001	3	4
LUNG_SCLC	ID4 →	+2.110	+0.933	.001	.001	3	4
STOMACH	CBFA2T2 →	+1.261	+1.429	.003	.005	3	4
SKIN	PITPNM2 →	+1.026	+1.688	.006	<.001	3	4
LARGE_INTESTINE	MATN4 →	+0.134	+1.349	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043584 vs ALDH1A3 — LARGE_INTESTINE

Explore this scatter interactively →