Regulation of respiratory gaseous exchange

Across TCGA patient cohorts, RNA activity of the Regulation of respiratory gaseous exchange pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1R, SERPINF1, and SRPX2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of respiratory gaseous exchange activity versus C1R in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C1R →	+0.532	+0.048	<.001	<.001	3	8
BRCA	SERPINF1 →	+0.826	+0.054	<.001	<.001	3	7
BRCA	SRPX2 →	+0.942	+0.057	<.001	<.001	3	7
BRCA	AEBP1 →	+0.707	+0.048	<.001	<.001	3	7
LSCC	COL1A1 →	+0.724	+0.077	<.001	<.001	3	7
BRCA	MMP2 →	+0.509	+0.039	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043576 vs C1R — BRCA

Explore this scatter interactively →