Regulation of respiratory gaseous exchange

Across TCGA patient cohorts, RNA activity of the Regulation of respiratory gaseous exchange pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB34, KCNC2, and E2F2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of respiratory gaseous exchange activity versus ZBTB34 in LUAD (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ZBTB34 →	-0.335	-0.427	.002	.002	3	4
UCEC	KCNC2 →	+0.420	+0.226	.002	.007	3	4
HNSC	E2F2 →	-0.421	-0.420	.003	.004	3	4
PDAC	POLH →	-0.404	-0.785	<.001	<.001	3	4
CCRCC	MCM6 →	-0.366	-0.660	.008	.003	3	4
LUAD	VPS8 →	-0.155	-0.258	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043576 vs ZBTB34 — LUAD

Explore this scatter interactively →