Regulation of respiratory gaseous exchange

Across TCGA cell cohorts, RNA activity of the Regulation of respiratory gaseous exchange pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS12, TRIP10, and PLK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADAMTS12 grouped by Regulation of respiratory gaseous exchange-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ADAMTS12 →	+3.010	+1.277	.006	.001	3	4
LUNG_SCLC	TRIP10 →	+2.640	+1.568	.003	<.001	3	3
LUNG_SCLC	PLK2 →	+2.690	+1.005	.004	.001	2	4
LUNG_SCLC	RSU1 →	+1.802	+1.172	.003	<.001	3	3
LUNG_SCLC	ZIK1 →	-2.267	-1.019	.002	.006	3	3
LUNG_SCLC	ZFP3 →	-1.662	-1.196	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADAMTS12 by Regulation of respiratory gaseous exchange activity — STOMACH

Explore this box plot interactively →