Regulation of respiratory gaseous exchange

Across TCGA cell cohorts, RNA activity of the Regulation of respiratory gaseous exchange pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAPLN2, TPMT, and PTEN, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of respiratory gaseous exchange activity versus HAPLN2 in LARGE_INTESTINE (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HAPLN2 →	+0.304	+1.569	.001	<.001	3	3
PANCREAS	TPMT →	+1.516	+1.747	<.001	.001	3	3
PANCREAS	PTEN →	-0.831	-1.353	.001	.004	3	3
LUNG_NSCLC_LUAD	CHAC2 →	-0.956	-0.461	<.001	<.001	3	3
BLOOD_Myeloma	MYO1F →	+3.457	+1.854	<.001	<.001	3	3
BREAST	CTIF →	-1.327	-1.234	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043576 vs HAPLN2 — LARGE_INTESTINE

Explore this scatter interactively →