Peroxisomal transport

Across TCGA patient cohorts, RNA activity of the Peroxisomal transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IMPDH1, MAP7, and EEF2_S502, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peroxisomal transport activity versus IMPDH1 in GBM (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IMPDH1 →	-0.523	-0.061	<.001	<.001	3	5
GBM	MAP7 →	+0.513	+0.049	<.001	<.001	3	5
BRCA	EEF2_S502 →	-0.624	-0.033	.001	.001	3	5
BRCA	HSPA13 →	-0.453	-0.038	<.001	<.001	3	5
BRCA	NEPRO →	-0.317	-0.037	.001	<.001	3	5
GBM	DBR1_S514 →	-0.642	-0.048	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043574 vs IMPDH1 — GBM

Explore this scatter interactively →