Peroxisomal transport

Across TCGA patient cohorts, RNA activity of the Peroxisomal transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HDHD3, RNU6-1199P, and POLQ, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peroxisomal transport activity versus HDHD3 in OV (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HDHD3 →	+0.535	+0.374	<.001	.002	3	3
LSCC	RNU6-1199P →	+0.462	+0.208	.003	.001	3	3
LSCC	POLQ →	+0.658	+0.160	.007	.001	3	3
BRCA	EIF2AK1 →	+0.308	+0.669	.003	.001	3	3
UCEC	SPARCL1 →	-1.543	-0.722	.002	.004	3	3
UCEC	CHMP5P1 →	+0.626	+0.699	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043574 vs HDHD3 — OV

Explore this scatter interactively →