Peroxisomal transport

Across TCGA cell cohorts, RNA activity of the Peroxisomal transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRI1, ZNF585B, and ALG1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRI1 grouped by Peroxisomal transport-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MRI1 →	-0.455	-0.457	.007	.008	3	3
SKIN	ZNF585B →	-0.906	-0.640	.002	.008	3	3
BONE	ALG1 →	-0.773	-1.198	.008	.008	3	3
UPPER_AERODIGESTIVE_TRACT	SEC16A →	-0.796	-0.346	.008	.003	3	3
UPPER_AERODIGESTIVE_TRACT	TRIM44 →	-1.117	-0.332	.008	.005	2	4
UPPER_AERODIGESTIVE_TRACT	CFAP61 →	-0.246	-0.428	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRI1 by Peroxisomal transport activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →