Maintenance of DNA repeat elements

Across TCGA patient cohorts, RNA activity of the Maintenance of DNA repeat elements pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTK, CDC20, and HELLS, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of DNA repeat elements activity versus TTK in BRCA (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TTK →	+1.180	+0.769	<.001	<.001	3	8
BRCA	CDC20 →	+1.559	+0.765	<.001	<.001	3	7
LSCC	HELLS →	+0.733	+0.409	<.001	<.001	3	7
HNSC	KIF18A →	+0.881	+0.251	<.001	<.001	3	7
HNSC	KNSTRN →	+0.741	+0.207	.001	.002	3	7
LSCC	CENPO →	+0.653	+0.547	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043570 vs TTK — BRCA

Explore this scatter interactively →