Maintenance of DNA repeat elements

Across TCGA cell cohorts, RNA activity of the Maintenance of DNA repeat elements pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSH3, TCF7L2, and CHST2, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of DNA repeat elements activity versus MSH3 in SOFT_TISSUE (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MSH3 →	+0.666	+0.123	<.001	<.001	3	11
SOFT_TISSUE	TCF7L2 →	+1.233	+0.101	<.001	<.001	3	8
SKIN	CHST2 →	-1.286	-0.085	.001	<.001	3	8
SOFT_TISSUE	RMI2 →	+1.015	+0.109	.002	<.001	3	8
BLOOD_Myeloma	BRI3BP →	+1.226	+0.081	.003	.006	3	8
BLOOD_Myeloma	MSH2 →	+1.100	+0.101	.003	.004	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043570 vs MSH3 — SOFT_TISSUE

Explore this scatter interactively →