Positive regulation of insulin-like growth factor receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of insulin-like growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM45, LOXL1-AS1, and BRD3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of insulin-like growth factor receptor signaling pathway activity versus TRIM45 in HNSC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRIM45 →	+0.799	+0.250	<.001	.007	3	5
HNSC	LOXL1-AS1 →	+0.455	+0.192	.001	<.001	3	5
CCRCC	BRD3 →	+0.366	+0.263	.002	<.001	3	4
BRCA	ZNF841 →	+0.584	+0.307	.003	.002	3	4
LSCC	CEP95 →	+0.389	+0.183	.001	.001	3	4
LSCC	SOX4 →	+0.822	+0.160	.007	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043568 vs TRIM45 — HNSC

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