Positive regulation of insulin-like growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of insulin-like growth factor receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SESN3, GGT7, and LYSMD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of insulin-like growth factor receptor signaling pathway activity versus SESN3 in OESOPHAGUS (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SESN3 →	+2.605	+2.206	<.001	<.001	3	3
BREAST	GGT7 →	-1.515	-1.208	.007	.003	3	3
BREAST	LYSMD1 →	-0.809	-1.275	.001	<.001	3	3
OESOPHAGUS	BIN1 →	-2.455	-2.006	<.001	<.001	3	3
PANCREAS	NOSTRIN →	-0.845	-1.284	<.001	.002	2	4
SKIN	ADCK5 →	-0.324	-1.833	.002	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043568 vs SESN3 — OESOPHAGUS

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