Regulation of translational initiation in response to stress

Across TCGA patient cohorts, RNA activity of the Regulation of translational initiation in response to stress pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HDGFL3, ZC3H14_S620, and RPL10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translational initiation in response to stress activity versus HDGFL3 in HNSC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HDGFL3 →	+0.350	+0.079	<.001	<.001	3	6
PDAC	ZC3H14_S620 →	-0.499	-0.027	.006	.006	3	6
BRCA	RPL10 →	-0.301	-0.035	<.001	.001	3	5
BRCA	CHKB →	+0.284	+0.047	.001	<.001	3	5
GBM	ELMO1 →	+0.465	+0.049	.001	<.001	3	5
GBM	HCLS1 →	+0.578	+0.036	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043558 vs HDGFL3 — HNSC

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