Regulation of translational initiation in response to stress

Across TCGA cell cohorts, RNA activity of the Regulation of translational initiation in response to stress pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PML, IRF1, and TMEM177, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translational initiation in response to stress activity versus PML in LIVER (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PML →	+1.470	+0.375	.001	.002	3	10
LIVER	IRF1 →	+2.483	+0.469	<.001	<.001	3	8
KIDNEY	TMEM177 →	-0.748	-0.362	.004	.004	3	8
LIVER	PSORS1C1 →	+1.915	+0.518	.006	.001	3	8
BONE	PLAU →	+3.936	+1.251	.005	.006	3	8
LUNG_SCLC	RRAS →	+2.237	+1.107	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043558 vs PML — LIVER

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