Regulation of translation in response to stress

Across TCGA patient cohorts, RNA activity of the Regulation of translation in response to stress pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEPTIN4, JAM3, and PRSS35, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translation in response to stress activity versus SEPTIN4 in BRCA (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SEPTIN4 →	-0.561	-0.209	<.001	<.001	3	8
CCRCC	JAM3 →	-0.783	-0.189	<.001	<.001	3	7
CCRCC	PRSS35 →	-0.768	-0.207	<.001	<.001	3	7
CCRCC	MGP →	-1.045	-0.166	.003	<.001	3	6
OV	CNRIP1 →	-0.639	-0.190	.006	.004	1	8
BRCA	FGF7 →	-0.991	-0.240	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043555 vs SEPTIN4 — BRCA

Explore this scatter interactively →