Regulation of translation in response to stress

pathway activity — cross-omics
GO:0043555Cross-omicsPROTEIN-MS → PROTEIN-MSCellPairwise association · TCGA cohorts

Across TCGA cell cohorts, RNA activity of the Regulation of translation in response to stress pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PML, UBE2L3, and FAF2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translation in response to stress activity versus PML in PANCREAS (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PANCREASPML →+1.877+0.280.009.007310
STOMACHUBE2L3 →-1.758-0.344<.001<.00139
STOMACHFAF2 →+0.853+0.281<.001<.00139
STOMACHNEDD8 →-1.850-0.343<.001<.00139
STOMACHSPCS3 →+1.073+0.246<.001<.00139
STOMACHILKAP →-1.363-0.308.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043555 vs PML — PANCREAS

Per-sample scatter of Regulation of translation in response to stress activity vs PML in PANCREAS.

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Exploration