Regulation of lipid kinase activity

Across TCGA patient cohorts, RNA activity of the Regulation of lipid kinase activity pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK7_S888, CLUAP1_S409, and KMT2D_S2251, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipid kinase activity activity versus DOCK7_S888 in OV (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DOCK7_S888 →	+0.590	+0.967	<.001	.001	3	4
UCEC	CLUAP1_S409 →	+0.633	+0.386	<.001	<.001	3	3
GBM	KMT2D_S2251 →	+0.289	+0.406	.003	.003	3	3
OV	RB1_S249 →	+0.756	+1.197	<.001	<.001	3	3
LSCC	RB1_T356 →	+1.282	+1.272	<.001	<.001	2	4
OV	SMARCA2_S1572 →	-1.150	-1.718	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043550 vs DOCK7_S888 — OV

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