Positive regulation of GTPase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of GTPase activity pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VKORC1, ZNF664, and PPP4R1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VKORC1 grouped by Positive regulation of GTPase activity-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	VKORC1 →	-1.383	-0.850	.001	.007	3	4
BLOOD_Leukemia	ZNF664 →	+1.148	+0.427	<.001	.006	3	4
URINARY_TRACT	PPP4R1 →	-0.904	-0.245	.003	.005	3	3
SKIN	VPS72 →	+0.606	+0.862	<.001	.005	3	3
OVARY	BTD →	-0.872	-0.817	.003	.009	3	3
UPPER_AERODIGESTIVE_TRACT	LTB4R →	-1.825	-0.194	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VKORC1 by Positive regulation of GTPase activity activity — OVARY

Explore this box plot interactively →