Protein acylation

Across TCGA patient cohorts, RNA activity of the Protein acylation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HDAC2, SMC1A, and ACTL6A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein acylation activity versus HDAC2 in HNSC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HDAC2 →	+0.381	+0.086	<.001	<.001	3	7
LSCC	SMC1A →	+0.228	+0.033	<.001	<.001	3	6
PDAC	ACTL6A →	+0.274	+0.019	.002	.004	3	6
PDAC	HCFC1 →	+0.186	+0.025	.001	<.001	3	6
COAD	LRRFIP1 →	-0.190	-0.017	<.001	.002	3	6
LSCC	MSH6 →	+0.486	+0.030	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043543 vs HDAC2 — HNSC

Explore this scatter interactively →