Protein acylation

Across TCGA patient cohorts, RNA activity of the Protein acylation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ISLR, PDGFRA, and EMILIN1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein acylation activity versus ISLR in CCRCC (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ISLR →	-2.020	-0.200	.009	.001	3	2
CCRCC	PDGFRA →	-1.860	-0.200	.003	.001	3	2
CCRCC	EMILIN1 →	-1.614	-0.185	<.001	.001	3	2
OV	ABCA9 →	-1.406	-0.282	<.001	<.001	3	2
OV	GREM2 →	-0.868	-0.351	<.001	<.001	3	2
OV	COL16A1 →	-2.184	-0.306	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043543 vs ISLR — CCRCC

Explore this scatter interactively →