Protein acylation

Across TCGA patient cohorts, RNA activity of the Protein acylation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UTP4, VIRMA, and CYBRD1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein acylation activity versus UTP4 in OV (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	UTP4 →	+0.609	+0.304	<.001	<.001	3	2
OV	VIRMA →	+0.308	+0.228	<.001	<.001	3	2
OV	CYBRD1 →	-0.612	-0.258	<.001	<.001	3	2
OV	LIN37_S138 →	+0.731	+0.200	<.001	<.001	3	2
OV	NRP2 →	-0.565	-0.176	.001	.001	3	2
OV	NUP93 →	+0.328	+0.269	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043543 vs UTP4 — OV

Explore this scatter interactively →