Protein acylation

Across TCGA cell cohorts, RNA activity of the Protein acylation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDX3, CDR2, and BNIP3L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRDX3 grouped by Protein acylation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRDX3 →	+0.692	+1.176	.007	<.001	3	4
CNS	CDR2 →	-0.827	-0.711	.001	.007	3	3
BLOOD_Lymphoma	BNIP3L →	-1.726	-0.351	.001	.009	3	3
LARGE_INTESTINE	RAE1 →	-0.702	-0.506	.001	.006	3	3
BREAST	STRA6 →	-2.096	-0.384	<.001	.005	3	3
KIDNEY	CTU2 →	+0.861	+0.822	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRDX3 by Protein acylation activity — BLOOD_Leukemia

Explore this box plot interactively →