Protein acylation

Across TCGA cell cohorts, RNA activity of the Protein acylation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VEZF1, RBM12B, and TTBK2, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein acylation activity versus VEZF1 in LARGE_INTESTINE (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VEZF1 →	+0.925	+0.048	<.001	<.001	3	12
BLOOD_Lymphoma	RBM12B →	+0.765	+0.035	<.001	<.001	3	12
LARGE_INTESTINE	TTBK2 →	+0.966	+0.064	<.001	<.001	3	12
STOMACH	CEP97 →	+1.080	+0.061	<.001	<.001	3	12
BONE	MIB1 →	+1.214	+0.056	.002	.003	3	11
LARGE_INTESTINE	MTMR9 →	+0.836	+0.056	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043543 vs VEZF1 — LARGE_INTESTINE

Explore this scatter interactively →