Protein acylation

Across TCGA cell cohorts, RNA activity of the Protein acylation pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BAG6, DNAJA1, and NAA50, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein acylation activity versus BAG6 in STOMACH (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	BAG6 →	+1.046	+1.121	.002	<.001	3	11
BONE	DNAJA1 →	+0.964	+1.074	<.001	<.001	3	8
BONE	NAA50 →	+0.952	+0.931	<.001	<.001	3	8
BONE	CCT5 →	+0.982	+1.253	<.001	<.001	3	8
BONE	CCT8 →	+1.051	+1.254	<.001	<.001	3	8
PANCREAS	DNAJC7 →	+1.730	+1.144	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043543 vs BAG6 — STOMACH

Explore this scatter interactively →