Endothelial cell migration

Across TCGA patient cohorts, RNA activity of the Endothelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC35E4, PIK3IP1, and SYNGR1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelial cell migration activity versus SLC35E4 in COAD (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SLC35E4 →	+1.568	+0.178	<.001	.001	3	1
COAD	PIK3IP1 →	+0.922	+0.178	.003	.001	3	1
COAD	SYNGR1 →	+0.808	+0.177	.003	.001	3	1
COAD	DGKH →	+0.957	+0.178	<.001	.001	3	1
COAD	IDS →	+0.724	+0.177	.003	.001	3	1
COAD	NOD1 →	+0.698	+0.177	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043542 vs SLC35E4 — COAD

Explore this scatter interactively →