Endothelial cell migration

Across TCGA cell cohorts, RNA activity of the Endothelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPIH, TMCC2, and KLHDC7A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPIH grouped by Endothelial cell migration-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PPIH →	-0.451	-0.501	.002	<.001	3	5
LARGE_INTESTINE	TMCC2 →	-0.779	-0.639	.007	.007	3	3
LARGE_INTESTINE	KLHDC7A →	+0.669	+0.653	.009	.006	3	3
LARGE_INTESTINE	DAZAP2 →	+0.520	+0.514	.008	.004	3	3
KIDNEY	RASD2 →	+1.494	+1.175	.001	.001	3	3
KIDNEY	PSMF1 →	+1.077	+1.107	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPIH by Endothelial cell migration activity — BREAST

Explore this box plot interactively →