Endothelial cell migration

Across TCGA cell cohorts, RNA activity of the Endothelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPKAPK2, CCDC138, and YIPF2, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelial cell migration activity versus MAPKAPK2 in SOFT_TISSUE (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MAPKAPK2 →	+0.797	+0.093	<.001	<.001	3	11
BLOOD_Leukemia	CCDC138 →	-0.876	-0.064	.002	<.001	2	11
LUNG_SCLC	YIPF2 →	+0.726	+0.116	.001	.002	3	9
BONE	SFXN4 →	-1.134	-0.131	<.001	.002	3	9
BONE	CHPF2 →	+1.632	+0.159	<.001	<.001	3	9
BONE	TGFB1I1 →	+3.199	+0.111	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043542 vs MAPKAPK2 — SOFT_TISSUE

Explore this scatter interactively →