Endothelial cell migration

Across TCGA cell cohorts, RNA activity of the Endothelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHN1, TBC1D32, and HMOX2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelial cell migration activity versus CHN1 in BLOOD_Lymphoma (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CHN1 →	-1.476	-0.315	<.001	<.001	3	6
OVARY	TBC1D32 →	-1.048	-0.233	<.001	.002	3	6
BLOOD_Leukemia	HMOX2 →	+0.600	+0.247	.001	.007	2	6
BLOOD_Lymphoma	LPXN →	+2.050	+0.292	<.001	.001	3	5
URINARY_TRACT	ZNF266 →	+1.537	+0.522	.002	.008	3	5
BLOOD_Leukemia	FERMT2 →	-1.128	-0.215	.003	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043542 vs CHN1 — BLOOD_Lymphoma

Explore this scatter interactively →