Endothelial cell migration

Across TCGA cell cohorts, RNA activity of the Endothelial cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PACSIN2, OSTF1, and ARPC3, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelial cell migration activity versus PACSIN2 in OESOPHAGUS (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PACSIN2 →	+1.485	+0.374	<.001	<.001	3	13
URINARY_TRACT	OSTF1 →	+2.090	+0.359	.009	.009	3	12
URINARY_TRACT	ARPC3 →	+1.293	+0.410	<.001	<.001	2	11
URINARY_TRACT	VASP →	+1.496	+0.305	.002	.008	2	11
URINARY_TRACT	ACTR3 →	+1.236	+0.384	<.001	<.001	3	10
URINARY_TRACT	ACTR2 →	+1.581	+0.453	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043542 vs PACSIN2 — OESOPHAGUS

Explore this scatter interactively →