Negative regulation of blood vessel endothelial cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of blood vessel endothelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BIK, CBX2, and MTHFSD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of blood vessel endothelial cell migration activity versus BIK in BLOOD_Lymphoma (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BIK →	+3.247	+0.291	<.001	<.001	3	5
BLOOD_Lymphoma	CBX2 →	+0.980	+0.287	.002	.002	3	5
LUNG_NSCLC_LUSC	MTHFSD →	+0.977	+0.411	.002	.003	3	4
BLOOD_Lymphoma	SRSF3 →	+0.817	+0.293	.001	<.001	3	4
BLOOD_Lymphoma	KLHDC3 →	+0.561	+0.279	.008	.002	3	4
BLOOD_Lymphoma	SLC25A19 →	+1.196	+0.400	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043537 vs BIK — BLOOD_Lymphoma

Explore this scatter interactively →