Positive regulation of neuron apoptotic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU6-720P, PDZRN3, and PRKG1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neuron apoptotic process activity versus RNU6-720P in COAD (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-720P →	+0.647	+0.560	.003	.002	3	3
PDAC	PDZRN3 →	+0.492	+0.539	.004	.003	3	3
PDAC	PRKG1 →	+0.326	+0.430	.001	<.001	3	3
PDAC	CLMAT3 →	+0.360	+0.614	.009	.001	3	3
PDAC	CKS1BP4 →	+0.310	+0.424	.001	.004	3	3
PDAC	KIF3C →	+0.266	+0.354	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043525 vs RNU6-720P — COAD

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