Positive regulation of neuron apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF139, PPFIBP2, and ZDHHC24, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF139 grouped by Positive regulation of neuron apoptotic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RNF139 →	-0.414	-0.641	.006	.009	3	4
BONE	PPFIBP2 →	+1.147	+1.051	.003	.003	3	4
LIVER	ZDHHC24 →	-1.205	-1.541	.001	.005	3	3
SOFT_TISSUE	SLC35C1 →	-1.020	-1.020	.002	.005	3	3
OVARY	GPN1 →	-0.526	-0.794	<.001	<.001	3	3
CNS	RHEB →	-0.777	-1.025	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF139 by Positive regulation of neuron apoptotic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →