Positive regulation of neuron apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF1, APOL6, and PARP14, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neuron apoptotic process activity versus IRF1 in LIVER (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	IRF1 →	+1.676	+0.079	<.001	<.001	3	13
BONE	APOL6 →	+2.187	+0.162	<.001	<.001	3	13
BLOOD_Lymphoma	PARP14 →	+2.175	+0.064	<.001	.002	3	12
BONE	DTX3L →	+1.968	+0.104	<.001	<.001	3	12
LIVER	IRF1-AS1 →	+1.619	+0.109	.001	.002	3	12
SOFT_TISSUE	TAPBP →	+1.335	+0.073	.003	<.001	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043525 vs IRF1 — LIVER

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