Negative regulation of neuron apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMG1, RN7SL333P, and ZBED6, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neuron apoptotic process activity versus SMG1 in DLBC (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	SMG1 →	+1.525	+0.039	<.001	<.001	3	33
CHOL	RN7SL333P →	+1.289	+0.030	<.001	<.001	3	33
CHOL	ZBED6 →	+2.775	+0.042	<.001	<.001	3	33
DLBC	EP300 →	+1.835	+0.039	<.001	<.001	3	32
UVM	DMXL2 →	+1.378	+0.028	<.001	<.001	3	32
CHOL	USP34 →	+2.020	+0.039	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043524 vs SMG1 — DLBC

Explore this scatter interactively →