Negative regulation of neuron apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S1PR1, SRPX, and ADAM33, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neuron apoptotic process activity versus S1PR1 in CCRCC (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	S1PR1 →	+0.779	+0.184	<.001	<.001	3	6
UCEC	SRPX →	+1.575	+0.232	.004	<.001	3	6
UCEC	ADAM33 →	+1.148	+0.145	<.001	<.001	3	6
CCRCC	LHFPL6 →	+0.810	+0.185	<.001	<.001	3	6
PDAC	FBLN5 →	+0.772	+0.198	<.001	<.001	3	6
CCRCC	RASL12 →	+0.805	+0.218	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043524 vs S1PR1 — CCRCC

Explore this scatter interactively →