Negative regulation of neuron apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIGD6, IGFL4, and NFE2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TIGD6 grouped by Negative regulation of neuron apoptotic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TIGD6 →	-0.574	-0.147	.002	.005	3	3
STOMACH	IGFL4 →	+1.720	+0.199	<.001	<.001	3	3
BREAST	NFE2 →	-0.389	-0.302	.003	.006	3	3
BREAST	CDH26 →	+0.832	+0.458	.001	.004	3	3
LIVER	NXNL2 →	-1.009	-0.207	<.001	.004	3	3
LARGE_INTESTINE	MAP1LC3B →	-0.621	-0.148	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TIGD6 by Negative regulation of neuron apoptotic process activity — STOMACH

Explore this box plot interactively →