Negative regulation of neuron apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRSS23, DPH5, and C8orf58, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neuron apoptotic process activity versus PRSS23 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PRSS23 →	-1.834	-0.253	.001	.001	3	4
BONE	DPH5 →	+0.764	+0.162	.002	.008	2	5
LIVER	C8orf58 →	+3.107	+0.464	<.001	.001	3	4
SKIN	ITGA2 →	-1.056	-0.155	.008	.007	3	4
LUNG_NSCLC_LUAD	RAVER2 →	+0.977	+0.175	<.001	.001	3	4
LUNG_SCLC	SH2D4A →	-1.237	-0.152	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043524 vs PRSS23 — UPPER_AERODIGESTIVE_TRACT

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